Case of The Year: A Preterm Infant with Liver Failure of Unknown Origin

This is a gripping and mysterious case study that begins with the premature birth of Baby C at 31 weeks and 6 days. What initially appeared to be a stable NICU course quickly unraveled into a complex clinical puzzle, as signs of liver failure emerged without a clear cause. A multidisciplinary team launched an urgent and expansive investigation, chasing down leads from metabolic disorders to rare infections. As the infant’s condition worsened—marked by seizures, cardiac arrhythmias, and coagulopathy—the mystery deepened, and time was running out. Unexpected test results cracked open the case, revealing a stealthy viral culprit and prompting a bold, compassionate-use treatment with an investigational antiviral. This case invites viewers to follow the twists and turns of a high-stakes diagnostic journey where every clue mattered, and the outcome hung in the balance.

Learning Outcomes:
Describe the aspects of a comprehensive diagnostic evaluation for a neonate with liver failure of unknown origin.
Identify the prevalence, possible presentation, and potential sequelae of the disease process that will be revealed in the case.
Explore potential options for supportive care and treatment for the disease process highlighted in the case.

CE Credit Information:

Participants can earn 1 CE credit for viewing the presentation and completing the evaluation.

The National Association of Neonatal Nurses is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.